???? ??? 4500????? ? ??? ????, ???? ???, ??? ???? ?? ?? ? ???? ????. ?? ???? ?? ???? ?? ??? ? ??? ?? ??? ??????. ???? ??? 4500? ??? ???? ????? ???? ???? ????, ? ??? ??? ??? ??? ???? ??? ?????. ?? ?????? ???? ??? 4500? ??, ??, ???, ??? ?? ??? ??? ???????.one. ???? ??? 4500??????? ??? 4500? 4500? CFU(Colony Forming Models)? ???? ??? ??? ??????? ?????